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Nerve Meister Real Customers Reviews It can be the result of inflammation, oxidative stress, damaged myelin sheaths, overactive nerve pathways, or a combination of these factors. This enzyme, when overactive, can break down the myelin sheath, which is the protective coating around your nerve fibers. Think of the myelin sheath like the insulation on an electrical wire—when it gets damaged, the signals traveling along your nerves can short-circuit, leading to pain, tingling, and numbness. When your nerves are constantly firing off pain signals, it can create a vicious cycle where the more pain you feel, the more sensitive your nerves become.