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Direct Meds GLP1 Reviews & Complaints When you take semaglutide or tirzepatide through Direct Meds GLP1, the medication travels through your bloodstream and binds to specific receptors in your brain, particularly in the hypothalamus, which is the part of your brain that controls appetite and energy balance. When you receive your medication from Direct Meds GLP1, you will get clear instructions on how to use it. If you choose the injectable form, you will use a small needle to inject the medication just under the skin of your abdomen, thigh, or arm once a week. Direct Meds GLP1 provides ongoing support from nurses who can answer your questions and help you troubleshoot any issues.